19 results
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
Alzheimer's (99% of cases ... Motor dysfunction: myoclonic ... incontinence, apraxia ... AlzheimersDisease #Dementia ... #pathophysiology
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
impairment • HIV dementia ... Pathophysiology ... integrity of the blood-brain ... motor slowing and ataxia ... #dementia #AIDS
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
relapse of bipolar disorder ... Dose-dependent tremor, ataxia ... dizziness, diplopia, ataxia ... Systemic effect -> Nausea ... #SideEffects #Pathophysiology
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology

Pulse pressure is the difference between the systolic blood
Diagnosis and Pathophysiology ... : • Valvular disorders ... Myeloproliferative disorders ... Differential #Diagnosis #Pathophysiology ... #causes #cardiology
Wolff–Parkinson–White syndrome (WPW) is one of several disorders of the electrical system of the heart that
one of several disorders ... WPW is caused by ... pathway between the atria ... #Pathophysiology ... #Diagnosis #Cardiology
Causes of Wide Pulse Pressure - Differential Diagnosis
Physiologic:
 • Advanced age-arteriosclerosis (less compliant arteries)
 • Well
Causes of Wide Pulse ... Pathologic: • Valvular disorders ... anemia (reduced blood ... Myeloproliferative disorders ... #cardiology
Tree in Bud Sign
The Tree-in-Bud sign represents Endobronchial spread in a linear branching pattern and centrilobular
It is caused by ... actually seen in all causes ... connective tissue disorders ... diagnosis #clinical #radiology ... #ChestCT #pathophysiology
High Output Heart Failure - Pathophysiology and Differential Diagnosis
Obesity - Systemic Vasodilation, Vasoactive Adipokines
Arteriovenous Fistula -
Heart Failure - Pathophysiology ... Myeloproliferative Disorders ... HeartFailure #CHF #Pathophysiology ... Differential #Diagnosis #cardiology ... #causes
Features of a Sickle Cell Crisis 
Sickle-cell disease - an autosomal recessive blood disorder.
Characterized by red
autosomal recessive blood ... disorder. ... go on to block blood ... Crises can be precipitated ... The underlying pathophysiology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Headache, Movement disorders ... , Seizure disorders ... Disease, PRES Pathophysiology ... autoantibodies that will cause ... thrombosis and/or blood-brain