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diagnosis differential rheumatology sle alzheimersdisease avascularnecrosis classification complications dementia dermatology erythematosus extraarticular geriatrics henochscholeinpurpura hsp iga management manifestations mucocutaneous myelitis
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Butterfly rash, Vasculitis ... Fits, Hemiplegia, Ataxia ... Glomerulonephritis Myositis(5%) Blood ... erythematosus #signs ... #symptoms #diagnosis
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
chromosome 21) Signs ... Motor dysfunction: myoclonic ... incontinence, apraxia ... AlzheimersDisease #Dementia #pathophysiology ... #symptoms
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
hair follicles -> causes ... endothelium) & Decr blood ... Livedo Reticularis, Vasculitis ... #diagnosis #signs ... #symptoms #complications
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... such as systemic lupus ... Presentation - Systemic Symptoms ... purpura: strong sign ... Large Vessel: Blood
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
vessels (vasculitis ... Decr delivery of blood ... inflammation tends to cause ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
endothelial lining of blood ... periumbilical region), nausea ... HenochScholeinPurpura #Pathophysiology ... #Diagnosis #Signs ... #Symptoms
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Episcleritis Signs ... Causes: - Idiopathic ... ’s syndrome - Lupus ... neutrophils in the blood ... Treatment: - Systemic
Avascular Necrosis: Pathogenesis and Clinical Findings • Physical Trauma (esp. to the scaphoid bone with damage
) • Multiple causes ... therapy - Lupus ... AvascularNecrosis #pathophysiology ... #diagnosis #signs ... #symptoms
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... • Bilateral signs ... and/or symptoms ... • Infectious causes ... - Sjogren - Vasculitis
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