18 results
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
Acting on the Nephron ... - Diuretics and ... HCTZ) 5) Potassium-sparing ... spironolactone) #Pathophysiology ... #Nephrology #Nephron
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
Localization of Renal ... loop of Henle Gitelman ... #Localization #Nephron ... #Defects #Pathophysiology ... #Nephrology
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Extra-renal Losses ... Loop and thiazide diuretics ... Bartter syndrome, Gitelman ... #causes #potassium ... #low #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Low Cl intake, Diuretics ... High Urine Cl-: Diuretics ... Bartter Syndrome, Gitelman ... hyperaldosteronism • High PRA: Renal ... #nephrology
Mechanisms of nephron damage in cardiorenal syndrome
 • Increased renal interstitial pressure
 • Hypoperfusion
 • Reduced
Mechanisms of nephron ... • Increased renal ... activities • Diuretic ... syndrome #Mechanisms #pathophysiology ... #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Low Cl intake, Diuretics ... High Urine Cl-: Diuretics ... Bartter Syndrome, Gitelman ... hyperaldosteronism • High PRA: Renal ... #Nephrology #Causes
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
hypokalemia • Renal ... Post-hypercapnia • Diuretics ... Bartter's syndrome, Gitelman's ... #causes #nephrology ... #potassium
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Hypokalemia Evaluation Algorithm ... suggests extra-renal ... Alkalosis: Emesis, Diuretics ... Bartter syndrome, Gitelman ... #nephrology #low
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Medications Renal ... Losses Non-renal ... • Discontinued diuretic ... #nephrology #low ... #potassium
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
with thiazide diuretic ... • Hypokalemia (renal ... potassium wasting ... Syndrome #diagnosis #nephrology ... #management #pathophysiology