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diagnosis vasculitis differential rheumatology mpo aav acute aki ana antibodies antibody antineutrophil antinuclear associated canca causes ddxof diseases glomerulonephritis hematology
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
associated with PR3 ... involvement - PR3 ... 75-90%, rarely PR3 ... disease - MPO>PR3 ... #PANCA #MPO #PR3
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
polyangiitis - MPO>PR3 ... polyangiitis - PR3 ... involvement - PR3 ... Churg-Strauss) - MPO>PR3 ... disease - MPO>PR3
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
proteinase 3 (PR3 ... in >90%, MPO > PR3 ... Granulomas - MPO > PR3 ... 80% (80-90% have PR3 ... proteinase 3 (PR3
ANCA Associated Vasculitis (AAV) - Auto-antibodies and Differential Diagnosis MPA → usually p-ANCA GPA → usually c-ANCA EGPA →
ANCA Associated ... EGPA → ANCA in ... 40-50% P-ANCA ... (MPO) C-ANCA ( ... PR3) X-ANCA (elastase
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Negative IF): • PR3 ... -ANCA (C-ANCA): ... > eGPA • MPO-ANCA ... (P-ANCA): eGPA, ... differential #diagnosis #algorithm
Frequency of ANCA Positivity in Different Conditions ANCA-Associated Vasculitis • GPA - PR3-ANCA 75%, MPO-ANCA 20%, 5%
Vasculitis • GPA - PR3 ... • MPA - PR3-ANCA ... • EGPA - PR3- ... positivity for MPO and PR3 ... sensitivity #MPO #PR3
A System for Vasculitides #Diagnosis #IM #Rheum #Vasculitis #Small #Medium #Large #Vessel #Size #Classification #ANCA #Differential
#Vessel #Size #Classification ... #ANCA #Differential ... #Algorithm #Ddxof
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Pauci Immune (ANCA ... proteinase 3 (PR3 ... in > 30 / MPO > PR3 ... hemoptysis, MPO > PR3 ... 90 percent have PR3
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Diagnosis Framework Pre-Renal ... Vasculitis • GN: ANCA ... nephrology #causes #algorithm
Subtypes of Serum Proteins Pre-albumin (Transthyretin) Albumin Globulins • Alpha-1: Alpha-1 antitrypsin, Serum amyloid A, Ceruloplasmin, Corticosteroid-binding globulin (Transcortin),
Serum Proteins Pre-albumin ... Proteins #Subtypes #algorithm ... #classification
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