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diagnosis management treatment medications nephrology pharmacology binders brash comparison differential druginduced evaluation high hypokalemia k pseudohyperkalemia reverse sarcoidosis signs symptoms
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... • Mechanism: Exchanges ... of aspiration #Potassium ... #Binding #Hyperkalemia ... #pharmacology #table
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
of Drug-Induced Hyperkalemia ... Heparin) • Sodium-channel ... • Increased EC ... differential #diagnosis #pathophysiology ... #pharmacology #potassium
Hyperkalemia - Management Algorithm • IV calcium • IV insulin and glucose and/or salbutamolt • Consider
Hyperkalemia - Management ... Algorithm • IV ... Dialysis Serum potassium ... and ECG changes ... #potassium #high
Medications for the Treatment of Hyperkalemia The goals of acute treatment are to prevent potentially life-threatening cardiac
eliminate excess potassium ... reduce dietary potassium ... , changes on ECG ... Figure 3 is an algorithm ... , and Table 3 summarizes
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 BRASH Syndrome B - Bradycardia R - Renal failure A - AV nodal blockade S - Shock H - Hyperkalemia Typical ECG
Typical ECG ... proportion to other findings ... of hyperkalemia ... • If on a Ca2+ channel ... diagnosis #management #pathophysiology
Emergent Hyperkalemia Treatment Algorithm ECG changes, weakness, K+ >6.5 Or renal insufficiency with K >5.5 with cellular
Emergent Hyperkalemia ... Treatment Algorithm ... ECG changes, weakness ... changes? ... treatment Remove potassium
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
heparinized tube) • ECG ... Elimination (see Table ... Treatments: • K-Binding ... Resins - Exchanges ... Management #Treatment #potassium
Pseudohyperkalemia vs Reverse Hyperkalemia Pseudohyperkalemia and reverse pseudohyperkalemia are both conditions where potassium levels appear falsely elevated. Pseudohyperkalemia: This
Pseudohyperkalemia vs Reverse Hyperkalemia ... No symptoms of hyperkalemia ... • ECG findings ... — if no changes ... in ECG despite
Evaluation and Management of Hypokalemia Hypokalemia is often asymptomatic. Evaluation begins with a search for warning signs
Hypokalemia is ... palpitations, changes ... electrocardiography (ECG ... depletion impedes potassium ... #Evaluation #Algorithm
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 Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
-60y (hormonal changes ... survival is 93-95% Pathophysiology ... hyperphosphatemia, hypercalcemia ... incidental CXR finding ... Self-limiting, chronic but stable
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