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diagnosis differential algorithm anemia aptt coagulation ekg elevatedmcv macrocytic macrocytosis management microcytic prolonged pt workup bleeding bruising classification criteria cryofibrinogenemia
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Destruction • Abnormal ... Sequestration Disordered ... Rare • Drugs (e.g ... #Hematology
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
Causes of Neutrophilia ... Solid Tumour (e.g ... • Metabolic disorders ... Myeloproliferative Disorder ... #Hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Causes of Splenomegaly ... • Thrombus (e.g ... Myeloproliferative disorders ... (eg. polycythemia ... #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Increased Requirement (e.g ... • Small Bowel Disorder ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Platelet Disorders ... function test, ANA (e.g ... or if a primary hematologic ... disorder is suspected ... #Workup #hematology
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... • Secondary (e.g ... Anemias (MAHA) - Abnormal ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... Chronic inflammatory disorders ... (e.g. autoimmune ... Differential #Diagnosis #Causes ... #hematology #secondary
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... (usually IgG) (e.g ... lymphoproliferative disorders ... Extravascular #Causes ... differential #diagnosis #hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... Iron Deficiency (Eg ... Causes: Chronic ... Other • e.g ... #Hematology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... for secondary causes ... eosinophilia (common causes ... signs or symptoms (eg ... Differential #diagnosis #hematology
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