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differential algorithm coagulation management anemia prolonged disorders laboratory workup bleeding bruising dic disseminated elevatedmcv intravascular macrocytosis mixing platelet rheumatology treatment
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
to Evaluate an Abnormal ... the PT or APTT ... Prolonging the PT ... to identify the cause ... #diagnosis #hematology
Algorithm for Investigation of Abnormal Coagulation Tests - Prolonged PT - Prolonged aPTT and Prolonged PT - Prolonged aPTT Dr.
Investigation of Abnormal ... Tests - Prolonged PT ... and Prolonged PT ... #Coagulation #Abnormal ... #Hematology #Diagnosis
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
PT (INR), Normal ... PTT, Normal PT ... , Normal PT (INR ... #Differential #Diagnosis ... #Hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and the aPTT ... amyloidosis #Abnormal ... #PT #aPTT #Prolonged ... #Causes #diagnosis ... #differential #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... PT and/or aPTT ... #PT #aPTT #Prolonged ... #Causes #diagnosis ... #differential #hematology
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
Plasma → Recheck abnormal ... PT and/or aPTT) ... Mixing #Study #diagnosis ... #hematology #pathophysiology ... #hematology #laboratory
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
- Differential Diagnosis ... /aPTT MAHA likely ... hemosiderin • PT ... /aPTT normal • ... Management #Algorithm #hematology
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
type 2B) • Normal ... PT/INR • Normal ... aPTT (prolonged ... VonWillebrand #Disease #Diagnosis ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... : INR/PT, aPTT(liver ... function test, ANA (e.g ... #Differential #Diagnosis ... #hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
mixing study (aPTT ... mild cases) • ... PT/INR & von Willebrand ... hemophilia type (e.g ... Management #treatment #hematology
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