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differential coagulation abnormal management disorders activation algorithm bleeding bruising dic disease disseminated evaluation hemophilia hemostasis inr intravascular macrophage mas mixing
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Step 1: Is the PT ... to identify the cause ... of Prolonged APTT ... #prolonged #diagnosis ... #hematology #evaluation
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... PTT, Normal PT ... PTT, Normal PT ... Differential #Diagnosis ... #Hematology #coagulation
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
PT and/or aPTT ... PT and aPTT 1. ... #aPTT #Prolonged ... #Causes #diagnosis ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and aPTT If ... aPTT are both prolonged ... #aPTT #Prolonged ... #Causes #diagnosis ... #differential #hematology
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
2B) • Normal PT ... INR • Normal aPTT ... factor VIII) Treatment ... VonWillebrand #Disease #Diagnosis ... #Hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
is prolonged, but ... normal in mild cases ... ) • PT/INR & von ... hemophilia type (e.g ... #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thrombocytopenia • Prolonged ... PT/PTT • Low ... INR < 2.3 - APTT ... #causes #treatment ... #management #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... : INR/PT, aPTT(liver ... function test, ANA (e.g ... #Differential #Diagnosis ... #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... prolonged after ... discern these causes ... #Differential #Diagnosis ... #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Hypofibrinogenemia • ↑ PT ... ↑ PTT • ↑ Fibrin ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
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