22 results
Anaphylaxis: Signs and Symptoms
Anaphylaxis: when any egg of three conditions is met:
1. Acute onset of skin/mucosal
Anaphylaxis: Signs ... Anaphylaxis: when any egg ... phase symptoms Signs ... Cardiac Compromise (e.g ... #Anaphylaxis #pathophysiology
Bradycardia
1) First Steps: IV, O2, Monitors, ECG, Pads on patient, Crash Cart in room. Is patient
O2, Monitors, ECG ... worsening brady, Signs ... Chest Pain • ECG ... Connect ECG Leads ... Set pacemaker to
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... ) Loop agents (eg ... Adenosine #Nephron #Pathophysiology ... Action #nephrology #pharmacology
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
cytokine synthesis, e.g ... Immunosuppressant #Drugs #Pharmacology ... #Pathophysiology
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Anticoagulants - Pathophysiology ... parenteral agents (e.g ... anticoagulant (e.g ... anticoagulant (e.g ... #Pharmacology #Pathophysiology
Primary Hyperthyroidism - Pathogenesis and Clinical Findings

Note: Although rare, gestational diseases can lead to thyrotoxicosis due
excess secretion of hCG ... Signs/Symptoms: ... endocrinology #pathophysiology
Fibrinolysis. 
Fibrinolysis occurs when plasminogen is activated to plasmin under the influence of factors such as
anticoagulant drugs (e.g ... Fibrinolysis #Pathway #Pathophysiology ... #Plasminogen #Pharmacology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
• Increased EC ... differential #diagnosis #pathophysiology ... #pharmacology #
Benign Prostatic Hyperplasia: Pathogenesis and Medications
Aging
 -> Increased Testosterone -> Testosterone metabolized into DHT by type
alpha-1 blockers (e.g ... -5 inhibitors (e.g ... anticholinergics (e.g ... Hyperplasia #Prostate #Pathophysiology ... #Medications #Pharmacology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... tissue expansion (e.g ... endocrinology #pathophysiology