838 results
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
) ANA or Anti-NucIear ... erythematosus (SLE ... erythematosus (SLE ... erythematosus (SLE ... Diseases: Lupus (SLE
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
ANA Patterns and ... erythematosus (SLE ... erythematosus (SLE ... erythematosus (SLE ... Antinuclear #Antibodies #ANA
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Highly specific for SLE ... searched for when ANA ... Association with both SLE ... higly specific for SLE ... rheumatology #table #ANA
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
erythematosus (SLE ... more specific for SLE ... 30% and 60% of SLE ... patients with SLE ... indicator that SLE
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Disease Associations ANA ... Non-specific; common in SLE ... RA Anti-dsDNA - SLE ... - Drug-induced SLE ... Diffuse) Anti-Sm - SLE
#paracetamol #paracetamoloverdose #NAC
#paracetamol #paracetamoloverdose
5-Oxoprolinuria
What is it:
 • Aka pyroglutamic acidosis, Intermediate in γ-glutamyl cycle
 • Amino acid transport and
Link to chronic paracetamol ... • Continuous paracetamol ... Diagnosis: • HAGMA; Paracetamol ... turnaround) • le ... HDU • Withdraw paracetamol
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Antinuclear (ANA ... manifestations • Neonatal SLE ... dysmotility • MCTD (SLE ... • Specific for SLE ... Erythematosus #SLE
Figure 1. The normal #pelvic #floor at rest during #rectal #examination. The #internal anal #sphincter #muscle
The #internal anal ... the #external anal ... demonstrates the internal anal
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus vs SLE ... Workup: - ANA ... Workup: - ANA ... management of SLE ... druginduced #lupus #sle