31 results
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group

< 5%
vasculitis - Diagnosis ... vasculitis Clinical ... manifestations - Skin ... with refractory disease ... #Vasculitis #Rheumatology
Dermatological semiology of Cutaneous Vasculitis 

Clinicopathologic correlations
 • Purpura, papules, pustules, necrosis: involvement of small vessels
Connective tissue disease ... EGPA • Solid cancers ... hemopathies (4%) • Cryoglobulinemia ... lesions #diagnosis #clinical ... manifestations #pathology
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
the Skin - Differential ... Skin Findings: ... Urticarial/LCV) - Cryoglobulinemic ... : • Behcet Disease ... #skin #dermatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
- Purpura - Skin ... Syndrome: • Clinical ... • Autoimmune diseases ... reticularis & skin ... classification #rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
• Pauci-immune vasculitis ... Rarely dominate the clinical ... purpura • Mixed cryoglobulinemia ... Polyangiitis #GPA #dermatology ... rash #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Purpura, ischemic skin ... ANCA +MPO) • Cryoglobulinemic ... Vasculitis - Skin ... Low levels mixed cryoglobulinemia ... differential #diagnosis #rheumatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... - Bone marrow disease ... Von Willebrand disease ... /HSP • Cryoglobulinemia ... Differential #Diagnosis #hematology
Cutaneous Manifestations of Monoclonal Gammopathy
 • Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic
deposits: Type I cryoglobulinemia ... activity: Type II cryoglobulinemia ... Cold agglutinin disease ... manifestations #dermatology ... #skin #clinical
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
malignancies, vasculitis ... Cryofibrinogenemia Clinical ... Diagnosis: • + Clinical ... Biopsy: Typical pathologic ... #hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
nose chondritis, skin ... thromboembolic disease ... recurrent fevers, vasculitis ... • Hematologic ... myeloid cells NEJM