9 results
ANCA-Associated Vasculitis
A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
necrotizing, small-vessel ... polyangiitis (GPA), microscopic ... involvement - PR3>MPO Microscopic ... #CANCA #PANCA # ... PR3 #Diagnosis #Rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... Vasculitis: • ... Microscopic polyangiitis ... #Antinuclear #Antibody ... antibodies #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
VASCULITIS: ANCA ... ): • Microscopic ... Vasculitis: + MPO-ANCA ... Dx: GPA, EGPA, microscopic ... differential #diagnosis #rheumatology
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
- Arteritis temporalis ... - ANCA-associated ... - Wegener granulomatosis ... - microscopic ... #Rheumatology #
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
c-ANCA - Vasculitis ... Wegener's granulomatosis ... p-ANCA - Vasculitis ... Microscopic polyangiitis ... diagnosis #table #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Urticarial/LCV) - Cryoglobulinemic ... ANCA Associated: ... - Microscopic ... Behcet Disease ... #rheumatology #
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Polyarteritis nodosa • Microscopic ... purpura • Mixed cryoglobulinemia ... • Giant cell arteritis ... blood vessels with ... #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
VASCULITIS: ANCA ... Pauci Immune (ANCA ... )): Microscopic ... No Granulomas (ANCA ... Differential #Diagnosis #Rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... - GPA, EGPA, microscopic ... Cutaneous small-vessel ... classification #rheumatology