14 results
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... Antibody) and ANCA ... Microscopic polyangiitis ... #ANCA #Antineutrophil ... antibodies #diagnosis #rheumatology
ANCA-Associated Vasculitis
A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
(GPA), microscopic ... - C-ANCA pattern ... ) - P-ANCA pattern ... PR3 Anti-GBM disease ... PR3 #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
): • Microscopic ... Vasculitis: + MPO-ANCA ... LFT • ESR • ANA ... Dx: GPA, EGPA, microscopic ... #rheumatology #
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
small vessels - ANCA-associated ... granulomatosis - microscopic ... polyangiitis ... - systemic lupus ... Vessels #Diagnosis #Rheumatology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
c-ANCA - Vasculitis ... granulomatosis p-ANCA ... - Vasculitis, e.g ... Microscopic polyangiitis ... diagnosis #table #rheumatology
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pauci-Immune: - ANCA-positive ... , Microscopic polyangiitis ... ) - ANCA-negative ... testing: anti-ANCA ... , anti-GBM ab, ANA
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antibody refers ... Using fluorescence microscopy ... : The ANA patterns ... #patterns #rheumatology ... #diagnosis #differential
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
ANCA Associated ... : - Microscopic ... polyangiitis ... : • Behcet Disease ... #rheumatology #
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... : ANCA Associated ... Pauci Immune (ANCA ... )): Microscopic ... #Rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
• Pauci-immune vasculitis ... Diagnosis: Vasculitis ... Polyarteritis nodosa • Microscopic ... Granulomatous vasculitis ... #rheumatology