15 results
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
receptor] • Thrombocytopenia ... MYH9-Related Disorder ... chain IIA • Thrombocytopenia ... #table #differential ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... with or without platelet ... Schistocytes, thrombocytopenia ... Consider RBC membrane disorder ... #Anemia #Differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... microangiopathy: Thrombotic thrombocytopenic ... lymphoproliferative disorders ... Extravascular #Causes #differential ... #diagnosis #hematology
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
Platelet disorders ... with qualitative defects ... #disorders #hematology ... #hemepath #differential ... #diagnosis #Aggregometry
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Platelet defects ... DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... #Diagnosis #hematology ... #nonpalpable #dermatology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Diagnosis Algorithm ... Thrombocytopenia ... - Quantitative Defect ... Platelet Function ... #Causes #Hematology
Platelet Disorders - Differential Diagnosis Framework

Qualitative Defects:
 • Adhesion
 • Aggregation
 • Secretion

Quantitative Defects:
 • Production:
Platelet Disorders ... - Differential ... #Disorders #Differential ... #Diagnosis #hematology ... #thrombocytopenia
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
and Platelet Disorders ... - Differential ... Diagnosis and Workup ... changes), high MCV anemia ... #Platelet #Disorders
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Thrombocytopenia ... . 1) HELLP (Hemolysis ... Liver tests, Low Platelets ... #Diagnosis #Comparison ... #Table
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Thrombocytopenia ... with coagulation defects ... . 1) HELLP (Hemolysis ... Liver tests, Low Platelets ... #diagnosis #table