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differential hematology management pulse hemolytic hepatology macrocytosis polycythemia secondary workup chronic clinical dermatology dyspnea effusion elevatedmcv endocarditis erythrocytosis extravascular generalized
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Decreased RBC ... Disease • Marrow ... Thalassemia • RBC ... Disorder • RBC ... #Algorithm #Causes
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Algorithm Decreased ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... #Algorithm #Causes
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Causes of False ... == Decreased RBC ... Glucose Content • RBC ... Reduction == Increase RBC ... Dilutional Effect • RBC
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... - Differential Diagnosis ... Algorithm Normal ... Neutrophils - Low RBC ... #Algorithm #Causes
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... , Liver diseases ... PD deficiency, Pulmonary ... coagulopathy (DIC) #RBC ... Morphology #Atlas #key #diagnosis
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... - Fe/TlBC, MCV/RBC ... TIBC Normal - MCV/RBC ... inclusions in RBC ... #Algorithm #Causes
Algorithm and Differential Diagnosis of Macroscopic Hematuria Important Historical Elements: - Painless: suggests malignancy - Painful: suggests calculi/infection - Urinalysis:
Algorithm and Differential ... Diagnosis of Macroscopic ... dysmorphic RBC’s, RBC ... /WBC casts, proteinuria ... intrinsic renal disease
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... Algorithm • Sickle ... hypertension • Unusual RBC ... acanthocytes - Consider RBC
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... Algorithm Persistent ... /RBC casts ... Minimal change disease ... #Algorithm #Causes
Causes of Wide Pulse Pressure - Differential Diagnosis Physiologic: • Advanced age-arteriosclerosis (less compliant arteries) • Well
Causes of Wide Pulse ... conditioned athletes Pathologic ... - Chronic pulmonary ... diseases • Arteriovenous ... #causes #cardiology
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