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management rheumatology lupus differential neurology druginduced erythematosus summary systemic cerebritis cns comparison dil disorders eosinophil eosinophilia hemophagocytic hlh hyperkalemia k
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Disorders Testing Algorithm ... evaluation or workup ... glucocorticoid treatment ... #Differential #diagnosis ... #hematology #eosinophilia
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
) - Diagnosis and ... • Immunologic Workup ... Positive in 60-80% of cases ... life-threatening • Treatment ... Erythematosus #Diagnosis
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Disease, PRES Pathophysiology ... autoantibodies that will cause ... #CNS #neurology ... #rheumatology #
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... constitutional symptoms • Treatment ... • Immunologic Workup ... life-threatening • Treatment ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Autoimmune diseases: SLE ... Treatment: • ... #management #treatment ... #summary #rheumatology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Algorithm Polycythemia ... Better call hematology ... some time, let’s see ... #Algorithm #workup ... #hematology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Hyperkalemia - Diagnosis ... reabsorption) Workup ... only if no clear cause ... and Elimination (see ... #potassium #nephrology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... Evaluate for NMO, SLE ... • Infectious causes ... Disorders: - SLE ... Transverse Myelitis Treatment
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
Prevalence: 1-2 cases ... Person Syndrome Pathophysiology ... antibody that works ... #Management #treatment ... #neurology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
is rare in DIL, SCLE-DIL ... • Immunologic Workup ... constitutional symptoms • Treatment ... Discontinuation of causal ... #diagnosis #treatment
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