17 results
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... of Action Diuretics ... Adenosine #Nephron #Pathophysiology ... #Action #nephrology ... #pharmacology
Nephron - Diuretic Sites of Action

Source Text: https://www.sciencedirect.com/book/9780323449427/critical-care-nephrology#book-info

#Nephron #Diuretics #Site #Action #Location #Nephrology #Pathophysiology #Pharmacology
Nephron - Diuretic ... Sites of Action ... #Site #Action # ... Location #Nephrology #Pathophysiology ... #Pharmacology
Mechanism of Action of Diuretics
Amiloride, Triamterene, Spironolactone
Loop Diuretics
Thiazides
Acetazolamide

#Diuretics #Mechanism #Action #pharmacology #pathophysiology #nephrology
Mechanism of Action ... of Diuretics Amiloride ... #Mechanism #Action ... #pharmacology # ... pathophysiology
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Hypokalemia - Differential ... Diagnosis Algorithm ... GI losses (NG suction ... • Discontinued diuretic ... Differential #Diagnosis #Algorithm
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
Algorithm for patients ... Non-reabsorbable anion ... Urine Cl - Loop diuretics ... , Thiazide diuretics ... #differential #algorithm
Renal Effect of NSAIDs Inhibition of Prostaglandin Synthesis

 - Renal disease, Cardiovascular disease -> Decreased renal
Heart failure, Diuretics ... synthesis, leaving actions ... Prostaglandins #Pharmacology ... #Pathophysiology
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... and Pathophysiology ... - Hyperkalemia ( ... , in states of hypokalemia ... #Pathophysiology
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
normal volume-based algorithm ... Renal Sodium loss (diuretics ... (AKI, Post-AKI diuresis ... ) RAAS Active (or ... Present (Uosm ≥100): Hypovolemia
Causes of Hypokalemia - Differential Diagnosis Algorithm
Decreased intake (rare cause in isolation)
GI loss - Urine loss
Differential Diagnosis Algorithm ... Vomiting • NG suction ... contracted • Loop diuretics ... syndrome • Thiazide diuretics ... Differential #Diagnosis #Algorithm
SGLT2 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits SGLT2 (sodium/glucose cotransporter 2) in the proximal tubule,
SGLT2 Inhibitors - Pharmacology ... Mechanisms of Action ... leading to osmotic diuresis ... AKI (likely from hypovolemia ... SGLT2 #Inhibitors #Pharmacology