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Nephron - Diuretic Sites of Action

Source Text: https://www.sciencedirect.com/book/9780323449427/critical-care-nephrology#book-info

#Nephron #Diuretics #Site #Action #Location #Nephrology #Pathophysiology #Pharmacology
Nephron - Diuretic ... /critical-care-nephrology ... book-info #Nephron #Diuretics ... #Pathophysiology ... #Pharmacology
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... - Diuretic Sites ... Adenosine #Nephron #Pathophysiology ... #Action #nephrology ... #pharmacology
Mechanism of Action of Diuretics
Amiloride, Triamterene, Spironolactone
Loop Diuretics
Thiazides
Acetazolamide

#Diuretics #Mechanism #Action #pharmacology #pathophysiology #nephrology
Mechanism of Action of Diuretics ... Acetazolamide #Diuretics ... Mechanism #Action #pharmacology ... #pathophysiology ... #nephrology
Mechanisms of thiazide diuretic side effects

Dr. Muner Mohamed @MunerMohamed1

#thiazide #diuretic #pharmacology #pathophysiology #sideeffects #adverseeffects #nephrology
Mechanisms of thiazide diuretic ... #thiazide #diuretic ... #pharmacology # ... pathophysiology ... adverseeffects #nephrology
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
Causes of Hypernatremia ... - Differential ... • Osmotic diuresis ... #Diagnosis #Causes ... #nephrology #sodium
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... agent • Does not cause ... #Metformin #Pharmacology ... #Summary #DM2 # ... diabetes #endocrinology
Hypophosphatemia - Differential Diagnosis Algorithm

Transcellular Shift
 • Recovery From DKA
 • Refeeding Syndrome
 • Acute Respiratory
Hypophosphatemia - Differential ... Syndrome • Osmotic Diuresis ... #LowPhosphate #Differential ... Diagnosis #Algorithm #endocrinology ... #causes
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... Thiazides diuretics ... #Pharmacology # ... nephrology #conversion ... loop #thiazide #classes
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Causes of Hypokalemia ... , Osmotic diuresis ... #Hypokalemia #Causes ... #differential # ... diagnosis #nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm
Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Causes of Hyponatremia ... - Differential ... Pain/Post-op • Neurologic ... especially thiazide diuretics ... #Differential #