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diagnosis hemeonc anemia aplastic apml arterial chronic cll differential differentiation embolism hemophagocytic heparin hit hlh induced leukemia leukostasis lymphocytic lymphohistiocytosis
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
Diagnosis and Management ... ♀, ↑Age, ESRD Pathophysiology ... • Serotonin Release ... Management: • ... #Treatment #Hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... WBC >100k, + lab signs ... : • Pathophysiology ... TLS #diagnosis #management ... #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
• Nephrotic Syndrome ... Liver, IBD • COVID ... Heparin-induced thrombocytopenia ... Venous #Arterial #pathophysiology ... #hematology #differential
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... infections/fevers • Thrombocytopenia ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... Neutropenia, anemia, thrombocytopenia ... • Richter’s Syndrome ... diagnosis #workup #oncology ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Differentiation #Syndrome ... APML #diagnosis #management ... #hematology #oncology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
standing for: - Thrombocytopenia ... cell lymphoma Pathophysiology ... TAFRO #diagnosis #management ... #rheumatology # ... Thrombocytopenia
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... Presentation • Common Signs ... Cytopenias (anemia, thrombocytopenia ... Pathophysiology ... #Hematology #HemeOnc
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