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Nephron - Diuretic Sites of Action

Source Text: https://www.sciencedirect.com/book/9780323449427/critical-care-nephrology#book-info

#Nephron #Diuretics #Site #Action #Location #Nephrology #Pathophysiology #Pharmacology
Nephron - Diuretic ... #book-info #Nephron ... #Diuretics #Site ... #Pathophysiology ... #Pharmacology
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... Adenosine #Nephron ... #Pathophysiology ... #Action #nephrology ... #pharmacology
Renal Actions of Diuretics

#Diuretics #Sites #Action #Nephron #Pharmacology #Nephrology
Renal Actions of ... Diuretics #Diuretics ... Sites #Action #Nephron ... #Pharmacology # ... Nephrology
Mechanisms of nephron damage in cardiorenal syndrome
 • Increased renal interstitial pressure
 • Hypoperfusion
 • Reduced
Mechanisms of nephron ... • Increased renal ... activities • Diuretic ... syndrome #Mechanisms #pathophysiology ... #nephrology
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
Hypernatremia - Differential ... Diagnosis Inadequate ... perspiration Renal ... • Osmotic diuresis ... #nephrology #sodium
Causes of Hyponatremia - Differential Diagnosis Algorithm
Hypovolemia, UNa > 20: 
 • Renal losses, Diuretic excess,
Hyponatremia - Differential ... Diagnosis Algorithm ... losses, Diuretic ... Ketonuria, Osmotic diuresis ... #Causes #nephrology
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
Hypernatremia - Differential ... Diagnosis Workup ... mOsm/kg - Implies renal ... , Ingestion Renal ... #Algorithm #nephrology
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Villous adenoma Renal ... chewing tobacco, Renal ... , Osmotic diuresis ... Hypokalemia #Causes #differential ... #diagnosis #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Diagnosis Algorithm ... Low Cl intake, Diuretics ... High Urine Cl-: Diuretics ... hyperaldosteronism • High PRA: Renal ... #nephrology
Hypomagnesemia - Differential Diagnosis
Renal Causes of Hypomagnesemia - Familial:
Bartter syndrome and Gitelman syndrome, Isolated recessive hypomagnesemia,
Hypomagnesemia - Differential ... Diagnosis Renal ... transplant, Diuretic ... #diagnosis #causes ... #nephrology #magnesium