13 results
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
inducers (↑) and inhibitors ... by inducers or inhibitors ... Chemotherapy #Oncology #Hematology ... #Interactions #Table ... #Pharmacology
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
#Medications #Pharmacology ... #Pathophysiology ... #Mechanisms #DOAC ... #Hematology
Summary table of the mechanism of action, side effect and contraindications of commonly used anti-coagulation drugs.
Summary table of ... Selective factor Xa inhibitors ... anticoagulation #pharmacology ... #medications #doac ... #comparison #table
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
Management of DOACs ... per treatment table ... direct thrombin inhibitor ... Rivaroxaban (anti-XA inhibitor ... Management #Treatment #pharmacology
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
LMWH, warfarin, DOACs ... direct factor Xa inhibitors ... direct thrombin inhibitors ... Deficiencies #Summary #table ... comparison #diagnosis #hematology
Selective Serotonin Reuptake Inhibitors: Mechanisms and Side Effects
 • Serotonin Syndrome:
   - Autonomic Hyperactivity:
Serotonin Reuptake Inhibitors ... SSRIs #Serotonin #Inhibitors ... #Pathophysiology ... #Pharmacology # ... Diagnosis #Signs #Symptoms
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Anticoagulants - Pathophysiology ... heparin (UFH): Inhibits ... anticoagulant that inhibits ... #Pharmacology #Pathophysiology ... Heparins #LMWH #UFH #DOAC
Serotonin-Norepinephrine Reuptake Inhibitors(SNRIs): Mechanisms and Side Effects

Withdrawal: Dizziness, Diarrhea, Insomnia, Nausea, Vomiting
Serotonin Syndrome - Potentially Life
Serotonin-Norepinephrine Reuptake Inhibitors ... SerotoninNorepinephrine #Inhibitors ... #Pathophysiology ... #Pharmacology # ... Diagnosis #Signs #Symptoms
Drugs for Depression and Anxiety Disorders

Selective Serotonin Reuptake Inhibitors
 • Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline,
Serotonin Reuptake Inhibitors ... PTSD, menopause symptoms ... • Inhibitors ... #Medications #Table ... #Pharmacology #
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
blood donor • Pathophysiology ... ARDS to explain symptoms ... transfusion • Pathophysiology ... Transfusion #Reactions #hematology ... diagnosis #comparison #table