20 results
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Associated Lactic Acidosis ... (MALA) Pathophysiology ... acidosis including ... LacticAcidosis #Toxicity #Toxicology ... #Diagnosis #Management
Colchicine Toxicity 
Naturally-occurring plant alkaloid [Autumn Crocus and Glory Lilly]
2-24 hrs 
 • Severe GI distress
Renal failure • Metabolic ... acidosis • ARDS ... Colchicine #Toxicity #Toxicology ... #Symptoms #Signs
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
show anion-gap metabolic ... acidosis 4) Presentation ... Labs: Anion-Gap Metabolic ... Acidosis, Respiratory ... Aspirin #Toxicity #Toxicology
Euglycemic Diabetic Ketoacidosis (EuDKA)
SGLT2 Inhibitors
Increasing Indications
Significant Adverse Drug Effects
Definition of EuDKA
 • Metabolic acidosis with pH
Definition of EuDKA • Metabolic ... acidosis with pH ... level < 200 mg/dL Pathophysiology ... EuDKA #diagnosis #management ... #endocrinology
Ketosis Disorders
Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
bodies are a normal metabolic ... by an anion gap acidosis ... fatty acid (FA) metabolism ... differential #diagnosis #management ... #endocrinology
Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
 - Little or no nutritional
• Incr Glucose Metabolism ... Syndrome - Metabolic ... Acidosis • Shift ... Syndrome #diagnosis #pathophysiology ... #symptoms #signs
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
acidosis (12-48 ... - Anion gap metabolic ... acidosis with both ... Poisoning #Toxicity #Toxicology ... #Diagnosis #Management
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
hypothyroidism Pathophysiology ... mitochondrial oxidative metabolism ... Hypothyroid #Myopathy #pathophysiology ... #signs #symptoms ... #endocrinology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... thickness) - metabolic ... #FeedbackLoop #endocrinology ... #pathophysiology
Propofol-Related Infusion Syndrome (PRIS)

Diagnosis is based on a constellation of clinical suspicion and biochemical signs including:
and biochemical signs ... Hyperlactatemia • Metabolic ... acidosis • Rhabdomyolysis ... PRIS #Diagnosis #Management ... Pharmacology #Toxicity #Toxicology