17 results
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
(MALA) Pathophysiology ... use in cellular metabolism ... via anaerobic metabolism ... also includes symptoms ... of metabolic acidosis
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
post-ingestion) - Symptom ... deterioration Shock and metabolic ... acidosis (12-48 ... - Anion gap metabolic ... acidosis with both
Stages of Iron Toxicity

Iron overdose can cause an anion gap metabolic acidosis. Severe cases can lead
Stages of Iron Toxicity ... cause an anion gap metabolic ... Recovery from GI symptoms ... Ill Shock and metabolic ... acidosisMetabolic
Colchicine Toxicity 
Naturally-occurring plant alkaloid [Autumn Crocus and Glory Lilly]
2-24 hrs 
 • Severe GI distress
Colchicine Toxicity ... Renal failure • Metabolic ... acidosis • ARDS ... #Colchicine #Toxicity ... #Toxicology #Symptoms
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... show anion-gap metabolic ... acidosis 4) Presentation ... ingestion/exposure Symptoms ... Labs: Anion-Gap Metabolic
Metabolic Acidosis with Anion Gap - KILU Mnemonic

K - Ketoacidosis
	• DKA
		- With normal glucose, ask if
Metabolic Acidosis ... normal glucose, ask ... (rare in lit), iron ... Mnemonic #AnionGap #Metabolic ... #Acidosis #diagnosis
Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
 - Little or no nutritional
• Incr Glucose Metabolism ... Syndrome - Metabolic ... Acidosis • Shift ... Constipation - MSK ... #symptoms #signs
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... free fatty acid metabolism ... Intermediate fatty acid metabolism ... postpartum): • Initial symptoms ... Monitor and Treat Complications
Anion Gap Metabolic Acidosis (AGMA) Differential Diagnosis - MUDPILES and GOLDMARK

M - Methanol
U - Uremia
D -
Anion Gap Metabolic ... Paraldehyde I - INH, Iron ... Iron overdose is ... and paraldehyde toxicity ... GOLDMARK #Anion #Gap #Metabolic
Refeeding Syndrome Overview

What Is It?
	• Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
from hormonal and metabolic ... severe clinical complications ... overload) Other Symptoms ... Differential #Diagnosis #Pathophysiology