40 results
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Acidosis (MALA) Pathophysiology ... use in cellular metabolism ... via anaerobic metabolism ... presentation - Clinical ... Toxicology #Diagnosis #Management
Complications of CKD
 - Patients with stages 1-3 ([GFR] >30 mL/min) of CKD are generally asymptomatic;
imbalances or endocrine/metabolic ... derangements are not clinically ... disturbances manifest clinically ... #Pathophysiology ... #Nephrology #CKD
Woltman’s sign on Physical Exam

53-year-old man presented with fatigue and sensitivity to cold. A physical examination
deep-tendon reflex, is a neurologic ... Reflexes #Delayed #Clinical ... #Video #Neurology ... #Endocrinology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... free fatty acid metabolism ... Intermediate fatty acid metabolism ... Maternal Support - Critical ... #pathophysiology
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
hypothyroidism Pathophysiology ... mitochondrial oxidative metabolism ... fibers Spectrum of Clinical ... Hypothyroid #Myopathy #pathophysiology ... signs #symptoms #endocrinology
Euglycemic Diabetic Ketoacidosis (EuDKA)
SGLT2 Inhibitors
Increasing Indications
Significant Adverse Drug Effects
Definition of EuDKA
 • Metabolic acidosis with pH
Definition of EuDKA • Metabolic ... level < 200 mg/dL Pathophysiology ... EuDKA #diagnosis #management ... #endocrinology
Asterixis due to Uremia on Physical Exam

29 year old male came in due to decreasing sensorium
high anion gap metabolic ... #PhysicalExam #nephrology ... #clinical #video
Myoedema in Hypothyroidism on Physical Exam

Hypothyroidism is a clinical syndrome resulting from the production, secretion or
Hypothyroidism is a clinical ... hormones, with varied clinical ... (shown in the video ... #video #neurology ... #endocrinology
Intracranial Hemorrhage (ICH) and Increased Intracranial Pressure (ICP) - Pathophysiology
ICH Management:
1. Manage Blood Pressure
  •
Pressure (ICP) - Pathophysiology ... ICH Management ... • Increased metabolic ... #neurology #neurosurgery ... #management
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
GrepMed Handbook Clinical ... Hypogonad (50%) • Metabolic ... malignancy Pathophysiology ... #Endocrinology ... #Treatment #Pathophysiology