17 results
Vitamin D Metabolism

#VitaminD #Metabolism #Pathophysiology #Endocrinology #Pathways
Vitamin D Metabolism ... #VitaminD #Metabolism ... #Pathophysiology ... #Endocrinology ... #Pathways
Vitamin D Metabolism Pathways

Dr. Jamie Willows @jamiekwillows

#VitaminD #Metabolism #Pathways #pathophysiology #endocrinology
Vitamin D Metabolism ... Pathways Dr. ... #Metabolism #Pathways ... #pathophysiology ... #endocrinology
Vitamin D Metabolism
Fat-soluble vitamin
Sources: dermal synthesis and food (dairy products, fish)
Active form: calcitriol (1,25-OH Vitamin D)
Main
Vitamin D Metabolism ... Fat-soluble vitamin ... mendesthiagob #VitaminD ... #Metabolism #endocrinology ... #pathophysiology
Steroid Synthesis Pathway

(OH, hydroxy; HSD, hydroxysteroid dehydrogenase; DHEA, dehydroepiandrosterone; pink, common enzymes affecting CAH, purple –
Steroid Synthesis Pathway ... Steroid #Synthesis #Pathway ... #metabolism #pathophysiology ... #endocrinology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates JAK-STAT pathway ... lipolysis Signs/Symptoms ... thickness) - metabolic ... #FeedbackLoop #endocrinology ... #pathophysiology
Hyperparathyroidism - Primary vs Secondary vs Tertiary 
Lab Comparison:
 • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
PTH, ↑Calcium, ↑Vitamin ... Phosphate Physical Symptoms ... pain Psychiatric Symptoms ... Hyperparathyroidism #diagnosis #endocrinology ... Secondary #Tertiary #pathophysiology
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
hypothyroidism Pathophysiology ... mitochondrial oxidative metabolism ... Hypothyroid #Myopathy #pathophysiology ... #signs #symptoms ... #endocrinology
Myoedema in Hypothyroidism on Physical Exam

Hypothyroidism is a clinical syndrome resulting from the production, secretion or
varied clinical symptoms ... There are several symptoms ... (shown in the video ... PhysicalExam #clinical #video ... #neurology #endocrinology
Refeeding Syndrome Overview

What Is It?
	• Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
from hormonal and metabolic ... Hypo-Mg2+ • Vitamin ... overload) Other Symptoms ... • Pellagra • Vitamin ... Differential #Diagnosis #Pathophysiology
Intracranial Hemorrhage (ICH) and Increased Intracranial Pressure (ICP) - Pathophysiology
ICH Management:
1. Manage Blood Pressure
  •
Pressure (ICP) - Pathophysiology ... Warfarin: Octaplex + Vitamin ... • Increased metabolic ... Pressure #ICP #Pathophysiology ... #neurology #neurosurgery