21 results
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
hypothyroidism Pathophysiology ... mitochondrial oxidative metabolism ... hypertrophy → Rhabdomyolysis ... #signs #symptoms ... #endocrinology
Hyperphosphatemia - Differential Diagnosis Algorithm
Transcellular Shift:
 • Rhabdomyolysis
 • Tumor Lysis
 • Metabolic or Respiratory Acidosis
Hyperphosphatemia - Differential ... Transcellular Shift: • Rhabdomyolysis ... Tumor Lysis • Metabolic ... HighPhosphate #Differential ... Diagnosis #Algorithm #endocrinology
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
Differential Diagnosis ... and Management ... , Heat stroke, Metabolic ... Dermatomyositis) AKI - Pathophysiology ... #Differential #
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Acidosis (MALA) Pathophysiology ... use in cellular metabolism ... also includes symptoms ... of metabolic acidosis ... Toxicology #Diagnosis #Management
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... free fatty acid metabolism ... postpartum): • Initial symptoms ... infiltration) Differential ... #pathophysiology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Differential Diagnosis ... Framework and Management ... Heat stroke - Metabolic ... : • Triad of symptoms ... #Differential #
Hypocalcemia - Diagnosis and Management
PTH Independent (↑ PTH)
 • LOW VIT D
    -
Diagnosis and Management ... Disease (CKD) - Metabolism ... Hypocalcemia #Diagnosis #Management ... #endocrinology ... #differential #algorithm
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
lipolysis Signs/Symptoms ... thickness) - metabolic ... #FeedbackLoop #endocrinology ... #pathophysiology
Refeeding Syndrome Overview

What Is It?
	• Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
from hormonal and metabolic ... overload) Other Symptoms ... Paresthesias • Rhabdomyolysis ... Syndrome #Nutrition #Differential ... #Diagnosis #Pathophysiology
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework

Heat Cramps:
 • Muscle pain or spasm -
Heat Stroke - Differential ... • Labs: - Metabolic ... acidosis - Rhabdomyolysis ... Collapse: • Pathophysiology ... Syncope • Signs/Symptoms