25 results
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Acidosis (MALA) Pathophysiology ... use in cellular metabolism ... via anaerobic metabolism ... includes symptoms of metabolic ... LacticAcidosis #Toxicity
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... no respiratory cause ... show anion-gap metabolic ... Labs: Anion-Gap Metabolic ... Salicylate #Aspirin #Toxicity
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
described phases of toxicity ... Abdominal pain, nausea ... deterioration Shock and metabolic ... - Anion gap metabolic ... Toxicology #Diagnosis #Management
Schematic representation of the major sources of ammonia production and its excretory pathway (GI = gastrointestinal,
although hepatic causes ... namely, the many causes ... and decreased metabolism ... Reye syndrome (Peds ... deficiency #Ammonia #Pathophysiology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... free fatty acid metabolism ... Intermediate fatty acid metabolism ... = nonspecific (nausea ... #pathophysiology
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia
If prolonged or ≥ 39 C this is a
dissipation of metabolic ... maintained fever CAUSES ... hyperthermia crisis (late sign ... Anesthesiology #Anesthesia #Checklist ... #Diagnosis #Management
Local Anaesthetic Toxicity - Guidelines for Crises in Anaesthesia
Signs of severe toxicity:
 • Sudden alteration in
Guidelines for Crises ... in Anaesthesia Signs ... Guidelines for crises ... Intraoperative #Checklist ... #Diagnosis #Management
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
out of cells may cause ... Due to neuronal metabolism ... Signs/Symptoms/Complications ... Abdominal pain, nausea ... DiabeticKetoacidosis #DKA #pathophysiology
Causes of Hypotonic Infant (Floppy Newborn) - Differential Diagnosis Algorithm
Central Nervous System - Decreased LOC, Axial
Causes of Hypotonic ... Infection • Metabolic ... Aminoglycoside Toxicity ... Dystrophies • Metabolic ... #Peds #Pediatrics
Propofol-Related Infusion Syndrome (PRIS)

Diagnosis is based on a constellation of clinical suspicion and biochemical signs including:
and biochemical signs ... Hyperlactatemia • Metabolic ... PRIS #Diagnosis #Management ... #Pharmacology #Toxicity