14 results
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Acidosis (MALA) Pathophysiology ... use in cellular metabolism ... also includes symptoms ... LacticAcidosis #Toxicity #Toxicology ... #Diagnosis #Management
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
no respiratory cause ... show anion-gap metabolic ... ingestion/exposure Symptoms ... Labs: Anion-Gap Metabolic ... Aspirin #Toxicity #Toxicology
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... Epidemiology: • 1-2 cases ... Pathophysiology ... Syndrome #diagnosis #management ... #treatment #neurology
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
Clozapine Toxicology ... effect on negative symptoms ... - Metabolism - ... Clozapine is known to cause ... Toxicity #Diagnosis #Pharmacology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... free fatty acid metabolism ... postpartum): • Initial symptoms ... = nonspecific (nausea ... #pathophysiology
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
Abdominal pain, nausea ... post-ingestion) - Symptom ... - Anion gap metabolic ... Poisoning #Toxicity #Toxicology ... #Diagnosis #Management
Guillain-Barré Syndrome (GBS)
Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness
Epidemiology:
 • Incidence: 1
Guillain-Barré Syndrome ... than one after symptom ... the underlying pathophysiology ... Syndrome #diagnosis #management ... #neurology
Intracranial Hemorrhage (ICH) and Increased Intracranial Pressure (ICP) - Pathophysiology
ICH Management:
1. Manage Blood Pressure
  •
Pressure (ICP) - Pathophysiology ... ICH Management ... = dilated BV = raises ... • Increased metabolic ... #management
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
Framework and Management ... Summary Causes ... Heat stroke - Metabolic ... : • Triad of symptoms ... #nephrology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
Etiology: • Pathophysiology ... Neurological symptoms ... Drug toxicity, Metabolic ... Syndrome #diagnosis #management ... #neurology