44 results
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
alkalosis • Normal ... ratio 0.5%) Differential ... Rhabdomyolysis Treatment ... Syndrome #diagnosis #nephrology ... #management #pathophysiology
Hypokalemia - Differential Diagnosis Algorithm

Transcellular Shift:
 • Alkalosis
 • ↑ beta-2 adrenergic simulation 
 • Erythropoiesis
Hypokalemia - Differential ... Transcellular Shift: • Alkalosis ... • G-CSF • Hypokalemic ... #Differential # ... Diagnosis #Algorithm #nephrology
Hypokalemia Differential Algorithm
Acidosis
 - RTA
 - Diarrhea
pH Normal 
 1. Decreased Mg 
 2. Intracellular Shift
Hypokalemia Differential ... Periodic paralysis Alkalosis ... Metabolic alkalosis ... #Differential # ... Causes #Workup #Nephrology
Acid-Base Disorders - Differential Diagnosis Framework

 • Respiratory Acidosis
 • Respiratory Alkalosis
 • Metabolic Acidosis
 •
Acid-Base Disorders - Differential ... • Respiratory Alkalosis ... • Metabolic Alkalosis ... Base #Disorders #nephrology ... #differential #
Causes of HyperKalemia - Differential Diagnosis
Increased extracellular K+:
 • Tissue injury
 • Hemolysis
 • Rhabdomyolysis
 •
Causes of HyperKalemia ... - Differential ... lysis syndrome • Metabolic ... blockers - MCW Nephrology ... #Differential #
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome Pathophysiology ... H+ secretion → Hypokalemia ... Metabolic alkalosis ... Gitelman #Syndrome #Pathophysiology ... #nephrology #diagnosis
Causes of Hyponatremia - Differential Diagnosis Algorithm
Hypovolemia, UNa > 20: 
 • Renal losses, Diuretic excess,
Hyponatremia - Differential ... Diagnosis Algorithm Hypovolemia ... tubal acidosis and metabolic ... alkalosis, Ketonuria ... Algorithm #Causes #nephrology
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Pressure: - Metabolic ... Alkalosis: Emesis ... Hippurate - Metabolic ... diagnosis #Algorithm #differential ... #potassium #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Primary Metabolic ... Alkalosis - Differential ... syndrome #Primary #Metabolic ... #Alkalosis #Differential ... Diagnosis #Algorithm #nephrology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic ... Alkalosis - Differential ... aldosteronism #Metabolic ... #Alkalosis #Differential ... Diagnosis #Algorithm #Nephrology