40 results
Ethylene Glycol Toxicity

#Pathophysiology #Toxicology #EthyleneGlycol #Metabolism #Fomepizole
Ethylene Glycol Toxicity ... #Pathophysiology ... EthyleneGlycol #Metabolism
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Acidosis (MALA) Pathophysiology ... use in cellular metabolism ... also includes symptoms ... of metabolic acidosis ... LacticAcidosis #Toxicity
Colchicine Toxicity 
Naturally-occurring plant alkaloid [Autumn Crocus and Glory Lilly]
2-24 hrs 
 • Severe GI distress
Colchicine Toxicity ... Renal failure • Metabolic ... #Colchicine #Toxicity ... #Toxicology #Symptoms
Gamma hydroxybutyrate (GHB) - Toxicology

Clinical presentation
 - Symptoms of GHB toxicity include: short term anterograde amnesia,
presentation - Symptoms ... of GHB toxicity ... depression - Symptoms ... GHB #Toxicology #Toxicity ... Diagnosis #Management #Pharmacology
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... show anion-gap metabolic ... ingestion/exposure Symptoms ... Labs: Anion-Gap Metabolic ... Salicylate #Aspirin #Toxicity
Antifungal Azoles - Antibiotics Class Overview

Mechanism:  inhibit ergosterol synthesis (important component of fungal cell membranes)
membranes) - Main metabolism ... hepatic, main toxicity ... Isavuconazole(PO or IV) #Pharmacology
Acetaminophen metabolism and factors affecting toxicity. 
GSH = glutathione 

#Acetaminophen #APAP #metabolism #toxicity #Toxicology #Pathophysiology #Overdose
Acetaminophen metabolism ... factors affecting toxicity ... Acetaminophen #APAP #metabolism ... #toxicity #Toxicology ... #Pathophysiology
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
described phases of toxicity ... post-ingestion) - Symptom ... absent in severe toxicity ... deterioration Shock and metabolic ... - Anion gap metabolic
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
effect on negative symptoms ... following first-pass metabolism ... - Metabolism - ... #Toxicology #Toxicity ... #Diagnosis #Pharmacology
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... free fatty acid metabolism ... Intermediate fatty acid metabolism ... postpartum): • Initial symptoms ... diagnosis #management #pathophysiology