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diagnosis algorithm differential injury druginduced gastroenterology treatment causes cirrhosis hepatitis lfts medications syndrome tests aclf activation aflp alcoholic carcinoma cardiology
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Drugs and Classes ... Associated with DILI ... and Type of Liver ... #LiverInjury #Hepatology ... #Pharmacology #
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 Drug-Induced Liver Injury - Pathophysiology Indirect Idiosyncratic Direct BWH Medicine Chiefs @BrighamChiefs #DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Drug-Induced Liver ... Injury - Pathophysiology ... BrighamChiefs #DILI ... #DrugInduced #Liver ... #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Hepatopathy • Acute ... (>1000): • DILI ... (Drug-induced liver ... Differential #Diagnosis #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Idiosyncratic Drug-induced ... Liver Injury (DILI ... #Drug #induced ... gastroenterology #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Drug Induced Liver ... exposure to HDS, drugs ... non-essential drug ... dechallenge • Acute ... Diagnosis #Algorithm #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Hepatitis (AAH) Drug-Induced ... Liver Injury (DILI ... Failure #Cirrhosis #Hepatology ... gastroenterology #management
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... Pregnancy (AFLP) Pathophysiology ... 10x ULN), ↑Tbili/Dbili ... #Pregnancy #hepatology ... #pathophysiology
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... bilirubin (Conjugated/DBili ... impaired uptake (drugs ... #Function #Tests ... Interpretation #diagnosis #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Vascular Causes of Acute ... • Iatrogenic: DILI ... Tests of synthetic function ... diagnosis #algorithm #hepatology
Managing warfarin INR Warfarin dosage must be individualized according to the patient's response to the drug, and
response to the drug ... #management #algorithm ... #pharmacology # ... #medications #table ... decisionaid #cardiology #hematology
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