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diagnosis differential hematology algorithm causes deficiency classification comparison macrocytic management table vitamin acute aplastic approach background chestxray congenital ct cxr
Causes of Vitamin B12 Deficiency - Cobalamin Decreased Intake Pancreas: Insufficiency Intestine: SIBO, Celiac disease, IBD, Lymphoma, Amyloidosis, Resection,
Causes of Vitamin B12 ... Deficiency - Cobalamin ... Stomach: Pernicious anemia ... pylori infection, B12 ... #Deficiency #Cobalamin
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
Vitamin B12 (Cobalamin ... - aka cobalamin ... Worsening macrocytic anemia ... wt loss • If anemia ... level (< 200 pg
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV Microcytic (MCV < 80) "TAILS": • Thalassemia
Algorithmic Approach to Anemia ... Sideroblastic anemia ... ACD, Aplastic anemia ... Folate deficiency, B12 ... MatthewHoMD #Anemia
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Morphological Approach - MCV ... ) Low MCV - <80fL ... patients) Normal MCV ... " High MCV - >96fL ... Megaloblastic: Vitamin B12
Causes of Low Vitamin B12 Levels Low vitamin B12 intake - Vegetarianism, chronic alcoholism and older people Autoimmune
of Low Vitamin B12 ... Levels Low vitamin B12 ... Autoimmune - Pernicious anaemia ... syndrome Food-bound cobalamin ... deficiency #low #cobalamin
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach to Anemia ... Reticulocytes, MCV ... , MCH, MCHC, Serum ... Deficiency • B12 ... • Anemia of Chronic
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Corpuscular Volume (MCV ... Poisoning • Anemia ... (>100 fL) • B12 ... #MCV #Classification
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
(MCV<80 fl), normocytic ... anemia (MCV 80- ... (MCV>100 fl). ... hemoglobin of less than 12 ... /mean MCV) × 100
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Corpuscular Volume (MCV ... - Low Serum B12 ... - Low Serum B12 ... • Rule out B12
Cobalamin (vitamin B12) In the diet: 5-15 pg/day (min. 1-5) B12 Protein HC pH t B12 Duodenum Stomach 1 B12 R-protein Protein From saliva R-protein Intrinsic factor Pancreas B12 R-Protein Trypsin B12 Terminal ileum B12 IF 2 Specific binding to receptors of
Cobalamin (vitamin ... B12) In the diet ... : 5-15 pg/day ( ... min. 1-5) B12 ... Protein HC pH t B12
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