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diagnosis hematology leukemia management chronic hemolytic hodgkins lymphocytic lymphoma monoclonal syndrome workup agglutinin algorithm apml atlas bandemia bloodcell calculation causes
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Headaches, bone pain, fever ... - infiltrates (anemia ... lymphoid organs When Cancer ... Lymphadenopathy • HSM • Fevers ... #Oncology #Diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... Lymphadenopathy • Fevers ... • Neutropenia, anemia ... diagnosis #workup #oncology ... #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
iron deficiency anemia ... Autoimmune hemolytic anemia ... RBC: Hemoglobin SS ... RBC #Morphology #differential ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Consider sickle cell ... diverse genotypes): SS ... bartonella (oroya fever
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Index < 2: • Anemia ... infiltration (e.g. cancer ... defects (e.g. sickle cell ... Production #Index #hematology ... #anemia #differential
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Lymphocytic Leukemia (CLL ... ) B symptoms → fevers ... 5) Symptoms of anemia ... uw_IMresidency #CLL ... Lymphocytic #Leukemia #oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
- Pel-Ebstein fever ... involvement Differential ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
general feeling of ill ... - Underlying cancer ... - Hematologic cancer ... Syndrome #diagnosis #dermatology ... #oncology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... malignancies -> CLL ... younger pts) Differential ... Symptoms: High fevers ... #hematology #diagnosis
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Left Shift: • Cell ... Neutrophil (Normal) Differential ... tachycardia or fever ... #differential # ... neutrophil #WBC #CBC #hematology
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