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diagnosis hematology differential algorithm management causes liver treatment anemia pathophysiology clinical cirrhosis workup oncology thrombocytopenia anticoagulation gastroenterology table syndrome pharmacology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Liver Injury (DILI ... Diagnosis Algorithm DILI ... injury, Previous DILI ... dates) Potential pitfalls ... Diagnosis #Algorithm #hepatology
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Associated with DILI ... #LiverInjury #Hepatology ... Pharmacology #Causes #DILI
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 Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Liver Injury (DILI ... ) DILI Types: ... • Cholestatic DILI ... EmoryGastroHep #DILI ... gastroenterology #hepatology
Drug-Induced Liver Injury - Pathophysiology Indirect Idiosyncratic Direct BWH Medicine Chiefs @BrighamChiefs #DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
BrighamChiefs #DILI ... Pathophysiology #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
(>1000): • DILI ... Differential #Diagnosis #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
• Iatrogenic: DILI ... Diagnosis #causes #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Liver Injury (DILI ... Failure #Cirrhosis #Hepatology
HFNC compared to NIV HFNC: - Comfort - Higher comfort Eating, drinking and speaking less impaired -
preload - P-SILI ... /VILI - Lower risk
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
• Iatrogenic: DILI ... Unconjugated Bili ... > 90% of Total Bili ... diagnosis #algorithm #hepatology
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
abnormality vs bone Bili ... Transaminitis #diagnosis #hepatology
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