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Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Liver Injury (DILI ... ) DILI Types: ... Chronic - ongoing ↑ LFTs ... • Cholestatic DILI ... EmoryGastroHep #DILI
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Liver Injury (DILI ... Diagnosis Algorithm DILI ... injury, Previous DILI ... dates) Potential pitfalls ... hepatitis #DILI
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Function Tests (LFTs ... (>1000): • DILI ... Function #Tests #LFTs
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Function Test (LFTs ... abnormality vs bone Bili ... #FunctionTest #LFTs
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Function Tests (LFTs ... bilirubin (Conjugated/DBili ... Function #Tests #LFTs
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Unconjugated Bili ... > 90% of Total Bili ... transaminitis #LFTs
The Liver Consult Primer - Guide to calling a consult HPI: - Start with reason for consult
- Vitals - LFTs ... GTT, indirect bili
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Failure (ACLF) Clinical ... Liver Injury (DILI
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Induced Lupus (DIL ... to 1:1 F:M • Clinical ... rash is rare in DIL ... for cutaneous DIL ... 40, F:M 9:1 • Clinical
Gynecomastia - Differential Diagnosis a nd Workup Algorithm Gynecomastia is common in clinical practice, affecting ~50% of males
Gynecomastia is common in clinical ... Labs: TSH, Cr, LFTs
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