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diagnosis hepatology differential algorithm transaminitis injury management laboratory tests causes function gastroenterology pathophysiology druginduced hepatitis workup abnormal alkphos calling chemistry
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Idiosyncratic Drug-induced Liver ... Injury (DILI) ... Chronic - ongoing ↑ LFTs ... or symptoms of liver ... Drug #induced #Liver
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Diagnosis Algorithm DILI ... injury, Previous DILI ... dates) Potential pitfalls ... hepatitis #DILI
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Tests (LFTs) - ... (>1000): • DILI ... (Drug-induced liver ... Function #Tests #LFTs
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... specific for the liver ... abnormality vs bone Bili ... #FunctionTest #LFTs
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Associated with DILI ... and Type of Liver ... Pharmacology #Causes #DILI
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 The Liver Consult Primer - Guide to calling a consult HPI: - Start with reason for consult
The Liver Consult ... Focus on prior Liver ... - Vitals - LFTs ... GTT, indirect bili ... US - Prior liver
Drug-Induced Liver Injury - Pathophysiology Indirect Idiosyncratic Direct BWH Medicine Chiefs @BrighamChiefs #DILI #DrugInduced #Liver #Injury #Pathophysiology #hepatology
Drug-Induced Liver ... BrighamChiefs #DILI ... #DrugInduced #Liver
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... (LFTs) - Normal ... nucleotidase - Liver ... bilirubin (Conjugated/DBili ... Function #Tests #LFTs
Liver Function Tests (LFTs) - Aspartate aminotransferase (AST) - Alanine aminotransferase (ALT) - Alkaline
Liver Function Tests ... (LFTs) - Aspartate ... Prothrombin #Liver ... Function #Tests #LFTs
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... Interpretation of LFTs ... Unconjugated Bili ... > 90% of Total Bili ... transaminitis #LFTs
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