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Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Platelet Disorders ... History: - Prior platelet ... - History of bleeding ... epistaxis, gingival bleeding ... Thrombocytopenia #Platelet
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Sequestration Disordered Platelet ... Coagulation #Bleeding ... Diagnosis #Algorithm #Causes
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Findings: • Bleeding ... Findings in DIC: • Platelet ... Thrombocytopenia - Platelet ... Treat primary cause ... Coagulation #diagnosis #causes
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
Bleeding manifestations ... areas of skin bleeding ... ecchymosis) is caused ... lowest levels Platelet ... ability to bind platelets
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... unusual bruising or bleeding ... skin that are caused ... by bleeding (petechiae ... Out Secondary Causes
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Bleeding and Bruising ... Qualitative defect in platelets ... characteristic of a platelet ... • Bleeding gums ... discern these causes
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
donor (apheresis) platelets ... Causes purpura & ... cause of transfusion ... coagulopathy & ↑bleeding ... more likely to cause
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... cause of transfusion ... common following platelet ... coagulopathy & ↑bleeding ... more likely to cause
Idiopathic Thrombocytopenic Purpura Clinical: • Gingival • Menorrhagia • GI bleeding • Intracranial
Menorrhagia • GI bleeding ... children) • Platelets ... only for severe bleeding ... extremely low platelet
Indications for Transfusion Packed RBCs • Hgb <7 g/dL or hematocrit <21% in a patient with uncompromised
hemoglobinopathy Platelets ... • < 30,000 and bleeding ... postoperative bleeding ... < 100,000 and bleeding ... Platelet transfusions
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