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diagnosis causes algorithm management clinical hematology cardiology table pulmonary nephrology radiology neurology dermatology mnemonic pathophysiology gastroenterology pediatrics workup comparison ddxof
Bleeding and Bruising - Differential Diagnosis Algorithm • Vascular System Defect - Congenital vs Acquired •
Bleeding and Bruising ... - Differential ... vs Acquired • Platelet ... vs Acquired #Bleeding ... #Bruising #Differential
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Leukocytosis - Differential ... B-symptoms, bruising/bleeding ... anemia, ↑ MCV, ↑/↓ platelets ... #Leukocytosis #Differential
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... / Bruising - Differential ... Sequestration Disordered Platelet ... Coagulation #Bleeding ... #Bruising #Differential
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Thrombocytopenia and Platelet ... Disorders - Differential ... - History of bleeding ... epistaxis, gingival bleeding ... #Disorders #Differential
Bleeding manifestations Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2
Bleeding manifestations ... areas of skin bleeding ... lowest levels Platelet ... ability to bind platelets ... VWF:RCo/VWF:Ag (differentiate
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Bleeding and Bruising ... of Hemostasis - Differential ... Qualitative defect in platelets ... characteristic of a platelet ... Bruising #Hemostasis #Differential
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
work properly, leading ... unusual bruising or bleeding ... to a low blood platelet ... are caused by bleeding ... blood count with differential
Idiopathic Thrombocytopenic Purpura Clinical: • Gingival • Menorrhagia • GI bleeding • Intracranial
Menorrhagia • GI bleeding ... children) • Platelets ... only for severe bleeding ... extremely low platelet
Indications for Transfusion Packed RBCs • Hgb <7 g/dL or hematocrit <21% in a patient with uncompromised
hemoglobinopathy Platelets ... • < 30,000 and bleeding ... postoperative bleeding ... < 100,000 and bleeding ... Platelet transfusions
Inherited Qualitative Platelet Defects Bernard-Soulier Syndrome • Defect of adhesion due to a lack of GP Ib/IX/V
Inherited Qualitative Platelet ... Single isolated platelets ... without platelet ... failure Grey Platelet ... comparison #table #differential
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