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diagnosis management comparison druginduced sle cppd differential drugs erythematosus syndrome systemic table activation algorithm associations autoantibodies calcium causes degenerative deposition
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... glycoprotein I (ß2GP), Lupus ... Myositis: Anti-JO-1, ... RNA Polymerase Ill
Immune Reactions and Immunosuppressant Drugs Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2 Muromonab-CD3 - Monoclonal antibody Calcineurin
., IL-1, IL-2 Muromonab-CD3 ... Basiliximab - IL ... Suppression of IL ... Immunosuppressant #Drugs #Pharmacology ... #Pathophysiology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
drug-dependent, 4:1 ... to 1:1 F:M • Clinical ... Prognosis: Usually mild ... Age 20-40, F:M 9:1 ... comparison #table #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... pneumonitis • ... CNS • Headache, mild ... • ANA titers > 1: ... Ro/La, anti-Jo-1,
Causes of Interstitial Lung Disease - Differential Diagnosis Algorithm Idiopathic Interstitial Pneumonia • (UIP) Usual Interstitial Pneumonia
this should be 1° ... Arthritis, Systemic Lupus ... Chronic Radiation Pneumonitis ... Lung #Diseases #ILD
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
-1 and IL-6, leading ... disease • Systemic lupus ... SJIA], systemic lupus ... Diagnosis #Management #Hematology ... #Rheumatology
Distinguishing between Inflammatory and Degenerative joint disease Inflammatory Joint Disease • Swelling stimulates joint nociceptors -> Pain
resolves after > 1 ... Rheumatoid arthritis, Lupus ... cartilage triggers a mild ... JointPain #Diagnosis #pathophysiology
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
trauma (> 65 years old ... disease states Pathophysiology ... arthritic flare. 1. ... to Manifest: 1. ... Gout #Comparison #rheumatology
Drug Induced Systemic Lupus Erythematosus > 100 drugs have been associated with drug-induced SLE High risk (>5%): •
Induced Systemic Lupus ... year Moderate (1- ... SLE #Systemic #Lupus ... medications #drugs #pharmacology ... differential #diagnosis #rheumatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... drug-dependent, 4:1 ... to 1:1 F:M • Clinical ... Prognosis: Usually mild ... #DIL #rheumatology
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