19 results
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... glycoprotein I (ß2GP), Lupus ... Myositis: Anti-JO-1, ... RNA Polymerase Ill
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
drug-dependent, 4:1 ... to 1:1 F:M • Clinical ... thiazidic, PPI, ACE, calcium-b ... Prognosis: Usually mild ... comparison #table #rheumatology
Immune Reactions and Immunosuppressant Drugs

Glucocorticoids - Inhibition of cytokine synthesis, e.g., IL-1, IL-2
Muromonab-CD3 - Monoclonal antibody
Calcineurin
., IL-1, IL-2 Muromonab-CD3 ... Basiliximab - IL ... Suppression of IL ... Immunosuppressant #Drugs #Pharmacology ... #Pathophysiology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... pneumonitis • ... CNS • Headache, mild ... • ANA titers > 1: ... Ro/La, anti-Jo-1,
Causes of Interstitial Lung Disease - Differential Diagnosis Algorithm
Idiopathic Interstitial Pneumonia
 • (UIP) Usual Interstitial Pneumonia
this should be 1° ... Arthritis, Systemic Lupus ... Chronic Radiation Pneumonitis ... Lung #Diseases #ILD
Digoxin Pharmacology and Pathophysiology
1) Na/K ATPase Pump - Digoxin works by directly binding to and inhibiting
Digoxin Pharmacology ... and Pathophysiology ... 1) Na/K ATPase ... CaitEKulig #Digoxin #Pharmacology ... #Pathophysiology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
-1 and IL-6, leading ... disease • Systemic lupus ... SJIA], systemic lupus ... Diagnosis #Management #Hematology ... #Rheumatology
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Effects: Edema (mild ... as necessary at 1- ... magnesium, and calcium ... level teaspoons) 1- ... #medications #pharmacology
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Epidemiology 1) ... Asian countries (1 ... survival is 93-95% Pathophysiology ... fibrosis. 4) Calcium ... skin (16-32%): lupus
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
Classification: CLASS 1 ... repolarization) CLASS 4 - Calcium ... Vaughan #Williams #Pharmacology ... Classification #Classes #pathophysiology