32 results
Who to test for BRCA 1/2?
Female Breast Cancer:
 • ≤ 45-50 years at diagnosis
 • Triple
test for BRCA 1/ ... 45-50 years at diagnosis ... relative meeting criteria ... #indications #oncology ... Cancer #screening #diagnosis
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
• Leukocytosis Diagnosis ... - Yamaguchi criteria ... 5 of the below criteria ... should be major: 1. ... #rheumatology #
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework

Heat Cramps:
 • Muscle pain or spasm -
- Differential Diagnosis ... Collapse: • Pathophysiology ... → Syncope • Signs ... heat stress • Criteria ... Multi-system illness: 1.
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
lateral sclerosis Pathophysiology ... ALS involves: (1) ... : months - Criteria ... : El Escorial criteria ... likelihood of this 1.
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
chest (in a V-sign ... Inverse Gottron’s sign ... Phenotype 1 ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
Attention Deficit Hyperactive Disorder (ADHD): Pathogenesis and clinical findings
 - For diagnosis, must have either 26
at > 17 years old ... than females (4:1) ... BehavioralDisorder #Pathophysiology ... #signs #psychiatry ... #criteria
Rheumatoid Arthritis Summary
Overview: chronic, inflammatory symmetric polyarthritis involving small joints of hands/feet, knees, shoulders
Signs & Symptoms:
knees, shoulders Signs ... AM stiffness, >1 ... : CLINICAL DIAGNOSIS ... Certolizumab, Golimumab), IL ... #management #rheumatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... opacities • Diagnosis ... symptoms, or> 1 ... #management #hematology ... #oncology
Evaluation of suspected incomplete Kawasaki Disease

1. AHA consensus recommendations
2. Infants ≤6 months old on day ≥7
Kawasaki Disease 1. ... Infants ≤6 months old ... have no clinical criteria ... clinical and lab signs ... #Diagnosis #Peds
Polycythemia Vera (PV) - Diagnosis and Management Summary
Diagnostic Criteria:
 • Elevated hemoglobin and/or hematocrit AND
 •
Management Summary Diagnostic ... Criteria: • Elevated ... erythropoietin 1/ ... present, symptoms, signs ... Summary #treatment #hematology