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diagnosis comparison differential management associations lupus pulmonary cppd dermatology erythematosus sle systemic abscess ana antibodies antimda5 antimda5dm antinuclear antinxp2 antinxp2dm
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... Drug-induced SLE Anti-Jo-1 ... Polymyositis / Dermatomyositis ... #diagnosis #table ... #rheumatology #
Connective tissue disease-associated interstitial lung diseases LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
interstitial lung diseases ... DM/PM : dermatomyositis ... ConnectiveTissueDiseases #ILD ... Differential #Comparison #Table ... #Pulmonary #Rheumatology
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Inflammatory Myopathies Dermatomyositis ... to 50X ULN • Autoantibodies ... anti-Mi-2, anti-TIF-1, ... diagnosis #comparison #rheumatology ... #table
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in ... Rheumatology • ... Myositis: Anti-JO-1, ... RNA Polymerase Ill ... #associations #table
On the left some diseases with a nodular pattern. 1. Hypersensitivity pneumonitis: ill defined centrilobular nodules. 2. Miliary
the left some diseases ... nodular pattern. 1. ... Hypersensitivity pneumonitis ... Hypersensitivity pneumonitis ... Differential #Comparison #Table
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
severity of the disease ... and ILD • Liver ... increases and ILD ... Phenotype 1 ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Anti-Ro/SSA autoantibodies ... , dermatomyositis ... • Acute lupus pneumonitis ... • ANA titers > 1: ... Ro/La, anti-Jo-1,
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Prognosis: Usually mild ... months) and of autoantibodies ... Evolution: Chronic disease ... sle #comparison #table ... #rheumatology #
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Association with disease ... syndromes Anti-PCNA 1- ... #Antinuclear #autoantibodies ... erythematosus #diagnosis #rheumatology ... #table #ANA
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
without these autoantibodies ... had more severe disease ... : • ILD was diagnosed ... Prednisone at 1 ... diagnosis #management #rheumatology
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