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diagnosis differential management dermatology symptoms cppd endocrinology fever hematology alzheimersdisease ana anca antibodies antibody antimda5 antimda5dm antineutrophil antinuclear antinxp2 antinxp2dm
Interstitial Lung Diseases (ILD) Exposure-Related ILD (a.k.a. extrinsic allergic alveolitis): • Hypersensitivity pneumonitis, Farmer's lung, Bird
Hypersensitivity pneumonitis ... ILD caused by inhalation ... , Polymyositis-dermatomyositis ... Churg Strauss syndrome ... differential #pulmonary #causes
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
chest (in a V-sign ... severity of the disease ... and ILD • Liver ... Phenotype 1 ... #rheumatology #
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
• Sjögren syndrome ... 1. ... Polymyositis and dermatomyositis ... 1. ... antibodies #diagnosis #rheumatology
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
Alzheimer’s Disease ... Onset Alzheimer's (1% ... - Presenilin 1 ... mutations - Down syndrome ... AlzheimersDisease #Dementia #pathophysiology
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
• Other rare causes ... hemianopsia IGF-1 ... Carpal Tunnel Syndrome ... Cardiovascular disease ... Overproduction #diagnosis #signs
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
, dermatomyositis ... Non-autoimmune rheumatologic ... • Acute lupus pneumonitis ... • ANA titers > 1: ... Ro/La, anti-Jo-1,
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Non-Infectious Causes ... • Behcet's syndrome ... fever • Hyper-IgD ... syndrome • Tumor ... Brucellosis Faget's Sign
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Myeloproliferative disease ... • Nephrotic Syndrome ... Ischemic Liver, IBD ... coagulation and other causes ... Venous #Arterial #pathophysiology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... Episcleritis Signs ... general feeling of ill ... Causes: - Idiopathic ... multiforme - Dermatomyositis
Cushing's Syndrome - Hypercortisolism - Diagnosis and Clinical Features 1) Skin • Thin, easily bruisable skin with
Cushing's Syndrome ... , oral cavity) Caused ... hyperglycemia —+ mild ... #Cushings #Syndrome ... Hypercortisolism #Diagnosis #signs
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