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diagnosis management erythematosus sle systemic table autoantibodies druginduced hematology activation ana antinuclear antiphospholipid apls associations classification comparison cryoglobulinemia cryoglobulins dermatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ... Anticoagulant (LAC) • Sjogren ... Syndrome: Anti-Ro ... Myositis: Anti-JO-1, ... RNA Polymerase Ill
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... heart block • Sjogren ... severe disease Treatment ... : • Mild disease ... Summary #diagnosis #rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
and Sjogren Anti-SSB ... -15% If SLE is clinically ... SLE-SSc-AlM overlap syndromes ... Anti-PCNA 1-5% ... erythematosus #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... dermatomyositis, Sjogren ... pneumonitis • ... • ANA titers > 1: ... Ro/La, anti-Jo-1,
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
-1 and IL-6, leading ... disease • Systemic lupus ... SJIA], systemic lupus ... Treatment: • Corticosteroids ... #Rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Prognosis: Usually mild ... • Clinical Manifestations ... life-threatening • Treatment ... comparison #table #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Pathways: - 1. ... : • Clinical triad ... RA - 5 to 20% Sjögren's ... (e.g. systemic lupus ... classification #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... salivary ducts Clinical ... • Interstitial Pneumonitis ... Adenocarcinoma Treatment ... #Syndrome #Rheumatology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rheumatic pain Clinical ... Diagnosis: • A clinical ... and lower jaw Treatment ... -1 inhibitors, IL ... #Rheumatology #
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
to 1:1 F:M • Clinical ... Prognosis: Usually mild ... constitutional symptoms • Treatment ... #DIL #rheumatology ... #diagnosis #treatment
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