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diagnosis management autoantibodies druginduced erythematosus hematology sle systemic activation ana antinuclear antiphospholipid apls associations cardiology chf comparison criticalcare dermatology differential
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... Myositis: Anti-JO-1, ... RNA Polymerase Ill ... #associations #table
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Prognosis: Usually mild ... • Clinical Manifestations ... sle #comparison #table ... #rheumatology #
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
-1 and IL-6, leading ... disease • Systemic lupus ... SJIA], systemic lupus ... Treatment: • Corticosteroids ... #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Clinical Features ... pneumonitis • ... • ANA titers > 1: ... Ro/La, anti-Jo-1,
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
-15% If SLE is clinically ... SLE-SSc-AlM overlap syndromes ... Anti-PCNA 1-5% ... erythematosus #diagnosis #rheumatology ... #table #ANA
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rheumatic pain Clinical ... Diagnosis: • A clinical ... and lower jaw Treatment ... -1 inhibitors, IL ... #Rheumatology #
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
typically fall into 1 ... & Dry) is the treatment ... acute coronary syndrome ... #differential #algorithm ... #table #foamed
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
to 1:1 F:M • Clinical ... Prognosis: Usually mild ... constitutional symptoms • Treatment ... #DIL #rheumatology ... #diagnosis #treatment
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Epidemiology: • F > M: 9:1 ... salivary ducts Clinical ... • Interstitial Pneumonitis ... Adenocarcinoma Treatment ... #Rheumatology #
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm INDICATIONS FOR TESTING: • Vascular thrombosis
Antiphospholipid Syndrome ... Hypercoagulable Workup Algorithm ... or more clinical ... excluded Testing: • Lupus ... #diagnosis #hematology
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