23 results
diagnosis hematology management oncology algorithm antinuclear aptt causes coagulation cytoplasmic pathophysiology prolonged pt syndrome testing workup aggregometry antinxp2 antinxp2dm antiphospholipid
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... SLE, SjS, CTD-ILD ... phenomenon - EJ, Jo-1, ... #differential # ... diagnosis #rheumatology
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
Clotting tests can be abnormal ... activity (e.g. antibody ... . 1:1 Mix of Patient's ... Study #diagnosis #hematology ... pathophysiology #hematology
Platelet disorders and Aggregometry Glanzmann Thrombasthenia • Defective aggregation to all agonists except ristocetin • Normal platelet,
similar aggregation pattern ... cytometry — GP Ilb ... agonists • This pattern ... either severe Type 1 ... Platelet #disorders #hematology
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Antinuclear Antibody ... SLE, SjS, CTD-ILD ... phenomenon • EJ, Jo-1, ... #differential # ... diagnosis #rheumatology
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
Microangiopathy (TMA) - Differential ... Diagnosis and Management ... schistocytes > 1% ... hemosiderin • PT/aPTT normal ... Management #Algorithm #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... FVIII antibody ... Jcortesizaguirr #Abnormal ... Causes #diagnosis #differential ... #hematology #coagulation
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Fever Patterns - ... Differential Diagnosis ... resolution falling to normal ... fever • Hyper-IgD ... #Differential #
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
levels - Usually normal ... products or D-dimer - Normal ... differential - ... Shows a mild leukocytosis ... Diagnosis #Workup #Hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
: < 1% Clinically ... ) Differential ... bacteremia • Abnormal ... #Bandemia #differential ... neutrophil #WBC #CBC #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Causes include : 1. ... amyloidosis #Abnormal ... Causes #diagnosis #differential ... #hematology #coagulation
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