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diagnosis differential hematology ana antinuclear cytoplasmic syndrome testing activation aggregometry antinxp2 antinxp2dm deficiency dermatomyositis disorders factoreight hemepath hemophilia hemophiliaa macrophage
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... SLE, SjS, CTD-ILD ... phenomenon - EJ, Jo-1, ... #Antinuclear #Antibody ... differential #diagnosis #rheumatology
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Antinuclear Antibody ... Testing Cytoplasmic Patterns ... SLE, SjS, CTD-ILD ... phenomenon • EJ, Jo-1, ... differential #diagnosis #rheumatology
Platelet disorders and Aggregometry Glanzmann Thrombasthenia • Defective aggregation to all agonists except ristocetin • Normal platelet,
similar aggregation pattern ... cytometry — GP Ilb ... agonists • This pattern ... either severe Type 1 ... Platelet #disorders #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
cytokines, such as IL ... -1 and IL-6, leading ... Increased soluble IL ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
-1 inhibitors, IL ... inhibitors, and IL ... SAPHO #Syndrome #Rheumatology ... #diagnosis #management ... #Dermatology
Hemophilia A Prophylaxis (Factor Eight Deficiency) Who Needs Prophylaxis? Primary Prophylaxis: • Severe deficiency (activity level <1%) even
activity level <1% ... bleeding episodes • Mild-to-moderate ... FactorEight #Deficiency #hematology ... #management #ppx
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
levels • NXP-2 antibody ... Prednisone at 1 ... Dermatomyositis #diagnosis #management ... #rheumatology # ... dermatology
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