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diagnosis differential lupus ana antibody cytoplasmic druginduced erythematosus patterns syndrome systemic testing activation arthritis comparison dil hematology joint macrophage mas
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Erythematosus - Summary Antinuclear ... • Specific for SLE ... Treatment: • Mild ... Summary #diagnosis #rheumatology ... #management
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... , SjS, CTD-ILD, ... phenomenon - EJ, Jo-1, ... ARUPLabs #ANA #Antinuclear ... differential #diagnosis #rheumatology
Antinuclear Antibody Testing Cytoplasmic Patterns Reticular/AMA: • PBC, SSc, PBC/SSc OS, PBC/SjS OS • AMA Speckled: •
Antinuclear Antibody ... , SjS, CTD-ILD, ... phenomenon • EJ, Jo-1, ... ARUPLabs #ANA #Antinuclear ... differential #diagnosis #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Prognosis: Usually mild ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... • Acute lupus pneumonitis ... CNS • Headache, mild ... • ANA titers > 1: ... Ro/La, anti-Jo-1,
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
lasting > 30 mins - 1 ... arthritis • SLE ... Symmetrical: • RA • SLE ... Differential #Diagnosis #MSK ... #rheumatology #
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
cytokines, such as IL ... -1 and IL-6, leading ... erythematosus [SLE ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ab • RF • Antinuclear ... • Interstitial Pneumonitis ... phenomenon (16%) MSK ... #Diagnosis #Management
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
varying degrees of: 1. ... Evaluate for NMO, SLE ... - Pleocytosis: Mild ... Disorders: - SLE ... Myelitis #diagnosis #management
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
to 1:1 F:M • Clinical ... is rare in DIL, SCLE-DIL ... Prognosis: Usually mild ... DrugInduced #Lupus #DIL #rheumatology ... diagnosis #treatment #management
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