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diagnosis rheumatology lupus treatment differential druginduced erythematosus summary systemic bcnie bloodculture cerebritis cns comparison dil disorders endocarditis hemophagocytic hlh infectiousdiseases
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... test, ANA (e.g., SLE ... (CVID, WAS), (neurologic ... - Bone marrow evaluation ... #Workup #hematology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
• Immunologic Workup ... Prognosis: Usually mild ... • Immunologic Workup ... of SLE • Evolution ... #diagnosis #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... • Immunologic Workup ... Positive in 60-80% of cases ... of SLE • Evolution ... #Summary #rheumatology
Management of Lupus Nephritis Lupus nephritis (LN) in 10 to 40% of SLE Hallmark = proteinuria 20.5 g/g
Management of Lupus ... in 10 to 40% of SLE ... renal histological evaluation ... #rheumatology # ... nephrology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... autoantibodies that will cause ... #CNS #neurology ... #rheumatology # ... cerebritis #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
cytokines (TNFa,lL1, IL6 ... Autoimmune diseases: SLE ... Drugs, Unknown cause ... inhibitors under evaluation ... Lymphohistiocytosis #diagnosis #management
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
BCNIE relies on evaluation ... but important causes ... See charts - ... antiphospholipid syndrome ... #differential #workup
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Hypocomplementemia • Can cause ... • Interstitial Pneumonitis ... Nephrogenic DI Hematologic ... Diagnosis #Management
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
is rare in DIL, SCLE-DIL ... • Immunologic Workup ... Prognosis: Usually mild ... Discontinuation of causal ... diagnosis #treatment #management
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