29 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
cytokines (TNFa,lL1, IL6 ... • Autoimmune diseases ... Lymphohistiocytosis #diagnosis #management ... #treatment #summary ... #rheumatology
Connective tissue disease-associated interstitial lung diseases

LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
interstitial lung diseases ... ConnectiveTissueDiseases #ILD ... #Differential #Comparison ... #Table #Pulmonary ... #Rheumatology #
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Rebound effect from treatment ... Inflammatory Conditions: Rheumatologic ... Vasculitides, IBD ... , Celiac disease ... : Chronic infections
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
age, however the disease ... can mimic common infections ... : • Infection ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Treatment
Primary HLH:
 - HLH-94 Protocol
    • Dexamethasone
steroids • In mild ... associated with infection ... or autoimmune disease ... #Treatment #management ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
Myelofibrosis Infectious ... Inflammatory: • IBD ... disorders • Celiac disease ... effect following treatment ... Algorithm #Causes #Hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
lymphohistiocytosis (HLH ... SLE], AOSD) • Infection ... Treatment: • Corticosteroids ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
, CF, IBD) • Anticoagulant ... Advanced Liver Disease ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Esophageal Crohn's Disease Management Algorithm

Assess for Active Symptoms and for Stricturing/Fistulizing Disease
Stricturing DX:
 • Bx r/o
Esophageal Crohn's Disease ... Management Algorithm ... Stricturing/Fistulizing Disease ... #Management #Algorithm ... #treatment #IBD
Adjuvant therapies in critical care: steroids to treat infectious diseases
 - Severe Community Acquired Pneumonia
steroids to treat infectious ... diseases - Severe ... jirovecii pneumonia, id ... #Pharmacology #Management ... #Treatment #Indications